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MSC Cruises to Africa

MSC Cruises Africa cruises are diverse and exciting, exploring everything from ancient pyramids in Egypt to guided safaris in natural reserves. Onboard the MSC Sinfonia, which sails all of MSC Cruise line’s African Cruises, guests will enjoy distinct Italian style, comfortable accommodations, countless activities, and more. In addition, on all MSC Cruises to Africa, kids sail free!

Showing 76-100 of 158 results
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 28, 2025 from Las Palmas, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 29, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 30, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals
Roundtrip
4-Night Africa Cruise
$419
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 01, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 05, 2025 from Las Palmas, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 07, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals
Roundtrip
4-Night Africa Cruise
$429
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 08, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
3-Night Africa Cruise
$339
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 12, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 12, 2025 from Las Palmas, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 14, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals
Roundtrip
4-Night Africa Cruise
$429
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 15, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
3-Night Africa Cruise
$379
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 19, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
7-Night Africa Cruise
$983
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 19, 2025 from Las Palmas, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$988
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 20, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$984
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 21, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals
Roundtrip
5-Night Africa Cruise
$659
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 22, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
7-Night Africa Cruise
$1,073
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 26, 2025 from Las Palmas, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$1,078
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 27, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals
Roundtrip
14-Night Africa Cruise
$1,729
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 27, 2025 from Durban, South Africa
Up to 1 deal
Roundtrip
7-Night Africa Cruise
$1,074
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 28, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 02, 2026 from Las Palmas, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 03, 2026 from Funchal, Madeira Islands, Portugal
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 04, 2026 from Santa Cruz de Tenerife, Spain
Up to 2 deals
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 09, 2026 from Las Palmas, Spain
Up to 2 deals
Roundtrip
2-Night Africa Cruise
$229
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 10, 2026 from Durban, South Africa
Up to 1 deal
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